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By Terry Wikle Shapiro

Stem phone and Bone Marrow Transplantation

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5. Butterini A, Goldman J, Keiting A, et al. Auto-transplants in chronic myelogenous leukemia: strategies and results. Lancet. 1990;1:255–1258. 6. Champlin RE, Ho WG, Nimer SD, et al. Bone marrow transplantation for severe aplastic anemia: recent advances and comparisons with alternative therapies. Presented at the UCLA Symposium on Molecular and Cellular Biology; Keystone, Colo; 1990;185–199. 7. Bacigalupo A. Bone marrow transplantation versus immunosuppression for the treatment of severe aplastic anemia (SAA): a report of the EBMT SAA working party.

Page 25 7. High-dose chemotherapy with autologous BMT/PBSC rescue for germ cell tumors 15 a) Autologous BMT/PBSC rescue for germ cell tumors is generally utilized in patients who have resistant or relapsed disease since the majority of patients are cured by conventional therapy alone. b) Recent studies have demonstrated a survival advantage in such patients when compared to conventional salvage therapy. c) Clinical trials are ongoing. 8. High-dose chemotherapy with autologous BMT/PBSC rescue for brain tumors15 a) Dose-intense carmustine is the primary drug of choice for conditioning regimens with autologous BMT/PBSC rescue in patients with brain tumors.

C) High-dose chemotherapy with autologous BMT or PBSC rescue has been used as both salvage therapy and consolidation therapy in patients who have demonstrated a response to cisplatin-based chemotherapy. 17 e) Only patients with nonbulky disease appear to benefit from high-dose chemotherapy with autologous BMT or PBSC rescue. f) Clinical trials are ongoing. 6. 15 a) Advanced melanoma is considered a relatively chemotherapy-resistant disease. However, dose escalation of alkylating agents plus autologous BMT demonstrated higher response rates than those seen with conventional chemotherapy.

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